ADCYAP1 and amyotrophic lateral sclerosis: In particular, it has been reported that the genetic depletion of PACAP in SOD1-G93A mice led to a loss of preganglionic parasympathetic and sympathetic neurons—which normally constitutively express PACAP—while sparing somatomotor neurons, indicating that PACAP has a neuroprotective role on visceromotor neurons in ALS (Ringer et al., 2013).