Many studies have shown that both people with DS and typical aging adults exhibit an auto-inflammatory or “inflammaging” syndrome (Trollor et al., 2012; Frasca and Blomberg, 2016; Ashraf-Ganjouei et al., 2020; Serre-Miranda et al., 2020) that might predict that GM-CSF treatment would be detrimental. Here, CSF2 is linked to Dravet syndrome.