Recently, high-throughput screens from our lab have identified several Food and Drug Administration (FDA)-approved drugs, including the anti-depressant drug imipramine and the anti-psychotic drug olanzapine, that inhibit the apoE-Aβ interaction and appear to improve cognition in AD patients, and especially in APOE4 carriers, in our retrospective analyses of human clinical data (Johnson et al., 2021a). The gene discussed is APOE; the disease is Alzheimer disease.