Our goals were to (1) test and compare two sets of modifiable risk scores (and their combination) to determine relative predictive power for EF trajectories, (2) identify whether the key AD genetic risk factor (APOE) moderates the expected associations between the modifiable risk scores and EF change, and (3) determine whether an AD-GRS influences the moderation between APOE and modifiable risk scores in predicting EF. The gene discussed is APOE; the disease is Alzheimer disease.