SLC12A5 and neurodevelopmental disorder: However, recent studies using mouse models with mutations impairing the phosphorylation of KCC2 at serine 940 and threonine 906/1007 residues revealed that these mice exhibited altered seizures susceptibility (Silayeva et al., 2015; Moore et al., 2018) and symptomatic manifestations of neurodevelopmental disorders (Moore et al., 2019; Pisella et al., 2019).