SOD1 and amyotrophic lateral sclerosis: Other studies have also suggested that astrocyte diversity is correlated with specific phenotypes in ALS, as exemplified by the observation that brain and spinal astrocytes from SOD1 (G93A) mice, a commonly used murine ALS model, display distinct inflammatory and neurotoxic phenotypes and impact differently on neuronal survival (Gomes et al., 2020; Barbosa et al., 2021).