SIRT1 and Cognitive impairment: Loss of synaptic plasticity is commonly known as the primary event correlated with cognitive impairment in AD, and several studies have documented that the accumulation of Aβ production or toxins in the brain promotes synaptic impairment via several mechanisms, including NOX and Sirt-1 (Gao et al., 2010[16]; Walsh et al., 2014[49]; Zhang et al., 2017[58]).