NFE2L2 and obesity due to melanocortin 4 receptor deficiency: Obesity-related increments in ROS production leads to activation of several redox-sensitive transcriptional regulators, including the nuclear factor-κB (NF-κB), activator protein-1 (AP-1), nuclear factor erythroid 2 related factor 2 (Nrf2), and FOXO1 (forkhead box O protein 1) (Fernández-Sánchez et al., 2011[35]; Klotz et al., 2015[63]; Bayliak et al., 2019[10]; Bayliak and Abrat, 2020[9]; Lushchak, 2021[78]).