BC cells induce release of IL-1β from myeloid and T cells via activation of the NLRP3 inflammasome, and IL-1β activates the transcription factors aryl hydrocarbon receptor (AhR) and retinoid-related orphan nuclear receptor gamma t (RORγt) to induce IL-22 production in memory cluster determinant 4-positive (CD4+) T cells to promote tumor growth [83]. This evidence concerns the gene IL1B and breast cancer.