After IL-1β-highly responsive clone (6D cells) from noninvasive MCF-7 BC cells were stimulated by IL-1β, the expression of CDKN1A/p21, TP63, small-fiber neuropathy (SFN), and especially BIRC3, was upregulated, which made BC cells resistant to doxorubicin [121]. This evidence concerns the gene BIRC3 and breast cancer.