In the cell model of BC cells (6D cells) with EMT induced by IL-1β through the activation of the IL-1β/IL-1R1/β-catenin pathway, upregulation of Twist1 resulted in methylation of the ESR1 gene promoter, which significantly reduced the level of ERα and increased the resistance to tamoxifen [120]. This evidence concerns the gene IL1R1 and breast cancer.