New studies have found that in HER2+ BC, overexpression of HER2 induces the expression and secretion of IL-1α, triggers the activation of other signal sequences including IL-6, and stimulates the NF-κB and STAT3 pathways to generate and maintain cancer stem cells (CSCs) and chronic inflammation to promote cancer initiation and progression [87]. The gene discussed is IL1A; the disease is breast cancer.