BC cell-derived IL-1α also induces expression of TSLP from tumor infiltrating myeloid cells, and TSLP, in turn, induces expression of B cell lymphoma-2 (Bcl-2) in tumor cells, promotes tumor cell survival, and skews the TME toward Th2 inflammation, sustaining lung metastatic survival [82]. The gene discussed is IL1A; the disease is neoplasm.