TGFB1 and breast cancer: These cytokines promote epithelial mesenchymal transition (EMT) and BC lymph node metastasis by upregulating TGF-β and vimentin, downregulating E-cadherin, and activating epidermal growth factor receptor (EGFR) (Tyr845) and NF-κB/p65 (ser276) signaling [109].