As the initial member of the IL-1 family, IL-1 has been recognized as a key immune and inflammatory mediator with important roles in tumorigenesis, invasion, metastasis, and tumor host interactions by mediating chronic inflammation, tumor angiogenesis, activation of the IL-17 pathway, induction of MDSCs, recruitment of macrophages, and skewing and suppression of antitumor immunity [9, 10]. Here, IL1A is linked to neoplasm.