In addition, upregulation of IL-1R8 in mammary epithelial cell transformation and primary BC decreased IL-1-dependent activation of NF-κB and proinflammatory cytokine production, inhibited activation of NK cells, and promoted M2-like polarization of macrophages, resulting in impaired innate immune sensing and T cell rejection of the TME [92]. This evidence concerns the gene NFKB1 and breast cancer.