Since several gaps exist in the present knowledge of factors affecting host susceptibility to dengue, the present study was done to study the association between genetic polymorphisms of TLR-2 [rs5743708 (Arg735Gln)and rs5743704 (Pro 631 His)], TLR-4 [A/G (Asp299Gly-13843) and rs4986791 C/T (Thr399Ile)], and VDR [rs731236 (Taq) and rs7975232(Apa1)] with susceptibility to dengue virus infection. Here, VDR is linked to dengue disease.