TLR4 and dengue disease: The host susceptibility to dengue may be influenced by host immune response and genetic factors,which includes single nucleotide polymorphisms (SNPs) of genes such as Toll like receptors 2 and 4 (TLR-2, TLR-4) present on the cytoplasmic membrane [2] and Vitamin D Receptor (VDR) present on nuclear membrane [3].Multiple important roles of VDR are known such as modulation of immunoregulatory effects of 1,25 dihydroxy vitamin D3, monocyte activation, stimulation of cellular immune responses, antagonism production of immunoglobulin and regulating lymphocyte proliferation[3].