It was earlier believed that TLR4 is activated only by the bacterial lipopopysaccharide (LPS) but now it is known that it also mediates immune response by NS1 antigen and other endogenous molecules of denguevirus [16,17] probably by regulation of cytokines like IL-6, TL-12 and interferons that are important in immune response against the virus [18].Similar to the results of our study, previous researchers have shown that heterozygous genotype of TLR4 Asp299Gly and TLR4Thr399Ile was significantly high in dengue cases than healthy controls [19]. Here, TLR4 is linked to dengue disease.