Previous studies have used plasma biomarkers to assess the risk of conversion from MCI to AD, such as plasma P-tau181, Aβ42/Aβ40, and neurofilament light [27, 28], and they have often focused on the evaluation of individual biomarkers, rather than systematically determining the best set of “A/T/N” markers for individualized prediction. Here, NEFL is linked to Alzheimer disease.