APOA4 and open-angle glaucoma: In the African American POAG subset, significant upregulation of four apolipoproteins was noted: APOA1 (FC = 1.34; p < 0.01), APOA2 (FC = 1.25; p = 0.02), APOA4 (FC = 1.37; p = 0.01), and APOD (FC = 1.19; p = 0.04) (Fig. 4).