Contrastingly, amongst the POAG subgroup, levels of APOA1 (ρ = − 0.51; p < 0.01), APOA2 (ρ = − 0.49; p < 0.01), and APOH (ρ = − 0.61; p < 0.01) had a negative correlation with cup shape measure. This evidence concerns the gene APOA2 and open-angle glaucoma.