Our study showed that APN suppressed proinflammatory factors (TNF-α and IL-6) through SIRT1- PINK1 signaling-mediated mitophagy, leading to inhibition of lung IR injury, which might mitigate the subsequent occurrence of acute graft rejection and obliterative bronchiolitis [6, 57]. The gene discussed is IL6; the disease is bronchiolitis obliterans syndrome.