Rs116405693, a novel index variant near CCSER1 (coiled-coil serine rich protein 1), was associated with PAD in individuals with diabetes (EAFdiabetes, 0.04, ORdiabetes [95% CI], 1.51 [1.32–1.74), Pdiabetes=2.5×10−9; Table and Figure III in the Data Supplement); but not in individuals without diabetes despite power to detect an effect (OR [95% CI], 0.97 [0.87–1.08], Pnodiabetes=0.58, Pinteractionwithdiabetes=5.3×10−7; power to detect in individuals without diabetes ≥80%, α=5.0×10−8; Figure III in the Data Supplement). The gene discussed is CCSER1; the disease is peripheral arterial disease.