Plasma PCSK9 levels were highest in patients with stable CAD due to the known effect of statins on raising PCSK9 expression (Table and Figure VII in the Data Supplement).14 The lipoprotein distribution of PCSK9 was determined using a modified sandwich ELISA across the entire cohort.15 A greater signal for apoA1–PCSK9 was observed when compared to apoB-PCSK9 and apo(a)-PCSK9 (Figure 5A). This evidence concerns the gene APOA1 and coronary artery disorder.