BRCA1 and ovarian carcinoma: The median times between events for ovarian cancer patients with BRCA1 mutations, hypermethylation of the BRCA1 promoter, and a negative methylation status of the BRCA1 promoter were 10.9 (95% CI: 7.6–15.9), 10.6 (95% CI: 8.0–12.5), and 12.0 (95% CI: 8.2–18.4) months, respectively (P = 0.84, log rank test; Fig. 4A).