These results, together with the increased proliferation in response to pasireotide in QGP‐1 cells, confirm the unexpected but limited ability of pasireotide to influence key functional parameters in PanNETs bearing SST5 and, at the same time, unveil an association between SST5 activation, expression of SSTR5 and its NAT, SSTR5‐AS1, and the actions of pasireotide on key features in cancer cells, proliferation, and migration, which warrant further investigations in PanNETs cells. This evidence concerns the gene SSTR5 and cancer.