Specifically, the CpG island overlapping the last exon of the NAT gene SSTR5‐AS1 was more methylated in somatotropinomas than in NP, whereas the one overlapping the first exon of SSTR5, and its putative promoter was hypomethylated in somatotropinomas compared to NP. The gene discussed is SSTR5; the disease is growth hormone-producing pituitary gland neoplasm.