Among them, somatotropinomas arise from somatotropes and oversecrete growth hormone (GH), causing gigantism (in children/adolescents) or acromegaly, characterized by extremity enlargement, facial and skeletal changes, and metabolic, gastrointestinal, cardiovascular, and respiratory complications [13, 14]. The gene discussed is GH1; the disease is growth hormone-producing pituitary gland neoplasm.