In fact, many of the CFTR rare alleles were also previously detected (as per CFTR1 database) in other CF populations residing around the Mediterranean basin, such as Q1476X (in Tunisia) [41], R1066C (in Southern Italy) [42], 4382delA (in Southern France) [43] and E379X (in Greece) [44], or reported in a Greek-Cypriot patient (M348K) [45]. This evidence concerns the gene CFTR and cystic fibrosis.