In addition, SKN inhibits pro-inflammatory cytokines including interleukin -6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin -12 (IL-12), interleukin -8 (IL-8), and interleukin -17A (IL-17A), and simultaneously induced anti-inflammatory interleukin-10 (IL-10), mediators interleukin-4 (IL-4) and transforming growth factor-β (TGF-β) in CIA mice and in anti-collagen monoclonal antibody-induced arthritis in mice as well as FLS in vitro [12–17]. Here, TNF is linked to arthritic joint disease.