On the other hand, pretreated groups (@, @@) (BBR 100 mg/kg, nano BBR 100 mg/kg (p < 0.01), 75 mg/kg, and 50 mg/kg (p < 0.05)) showed a significant reduction in TNF-α, IL-1B, and MDA levels compared to the stroke group. The gene discussed is TNF; the disease is stroke disorder.