ADCY8 and cancer: Among the 349 predicted miRNAs and 378 TFs, hsa-mir-372, hsa-mir-20 and hsa-mir-10b had the highest degree in the constructed interaction with real hub genes, such as GNG13, HTR1A and ADCY8. Hsa-miR-372 has been identified as both a tumor promoter and a tumor suppressor, depending on the type of cancer [28].