CYP2D6 and major depressive disorder: The CUA with model-based economic evaluation in the Netherland study showed that CYP2D6 screening for adjusting dose before starting nortriptyline compared to no screening would not be cost-effective since CYP2D6 was not potentially related to the reduction of ADRs and to the increased efficacy of nortriptyline in a major depressive disorder [73].