Interestingly, mitochondria and nutrient transporter related genes, such as glucose transporter-SLC2A1, intracellular calcium and amino acid transporter-SLC3A2, transporter activity regulator-SLCO4A1, and the physical barrier-CLDN5, were significantly increased, suggesting the increased uptake of nutrients and energy production in AD brain [83–85] (Fig.6B). This evidence concerns the gene CLDN5 and Alzheimer disease.