CLOCK and Alzheimer disease: These genes were enriched for glutamate receptors (down-regulated GRIA2 and GRM3), glutamate secretion (up-regulated SLC38A2), thyroid hormone perturbation (down-regulated SLCO1C1 and DIO2) [55, 56], extracellular matrix organization (ITGB8, ITGB4, and VCAN), circadian clock regulation (down-regulated CIRBP) [57], permeability of BBB (up-regulated PLEKHA5) [58], and cell proliferation (up-regulated RHPN1) [59], indicating the dysfunction of astrocytes and neurons in AD.