High levels of FGF23 are positively correlated with increasing blood pressure [16] and pulse pressure [17] in CKD, this may be due to impairment of endothelial dependent vasorelaxation [18], High levels of FGF23 are associated with arterial stiffness [19], atherosclerosis [19, 20] and aortic valve calcifications [21] in CKD. The gene discussed is FGF23; the disease is atherosclerosis.