Pembrolizumab, an anti-programmed death-1 (PD-1) antibody, or atezolizumab, an anti-programmed death ligand-1 (PD-L1) antibody, have demonstrated survival benefits over platinum-based chemotherapy in chemo-naïve patients with NSCLC [1, 2]. This evidence concerns the gene CD274 and non-small cell lung carcinoma.