AGRN and cardiac hypertrophy: Potential pathways were enriched with IPA (Fig. 1D), which mainly involved in two aspects: GPCR-mediated enteroendocrine signalings including melatonin signaling, l-carnitine biosynthesis, pyridoxal 5′-phosphate salvage pathway, and α-adrenergic signaling; and cardiovascular functions related to cardiac hypertrophy, agrin interactions, and eNOS signaling.