Effects of SNP or other NO-generating compounds in regulating blood glucose and insulin sensitivity have been tested sufficiently on cell and animal models of diabetes and human with diabetes, and all the results have shown that treatment of NO donor SNP or NO precursor L-Arginine reduce blood glucose levels, improve insulin resistance and lipid profiles in diabetic models [62–68], however, they do not affect blood glucose, lipid profile in non-diabetic group [69, 70]. Here, INS is linked to diabetes mellitus.