AMD‐mediated synergistic treatment could notably induce the upregulation of Bcl‐2 and downregulation of Bax, causing the imbalance between the two proteins, increasing mitochondrial outer membrane permeabilization, releasing pro‐apoptotic factors, and finally activating caspase cascades.57, 58, 59. This evidence concerns the gene BAX and age-related macular degeneration.