AMD‐mediated synergistic treatment could notably induce the upregulation of Bcl‐2 and downregulation of Bax, causing the imbalance between the two proteins, increasing mitochondrial outer membrane permeabilization, releasing pro‐apoptotic factors, and finally activating caspase cascades.57, 58, 59. Here, BCL2 is linked to age-related macular degeneration.