DICER1 and embryonal rhabdomyosarcoma: Heravi-Moussavi et al. conducted the first comprehensive analysis of DICER1 in OSCSTs and identified a DICER1 mutation in 60% of SLCTs, all of which were restricted to the RNase IIIb domain; in addition to a second germline mutation in a subset of cases; they also found DICER1 mutations in 1 of 14 nonseminomatous testicular germ cell tumors, 2 of 5 ERMS, and in 1 of 266 epithelial ovarian and endometrial carcinomas50.