DICER1 and rhabdomyosarcoma: Pathologically, most SLCTs in the DICER1 setting have been moderately (intermediate) or poorly differentiated tumors (Fig. 7A, B); some of these neoplasms have had heterologous elements including nodules of cartilage and rhabdomyosarcoma; the latter combination of patterns has been observed in SLCT in addition to PPB as already noted and in other DICER1-associated tumors (Fig. 8A–C)23,59.