FGF2 and glioblastoma: This model is used to recapitulate how individual components of the GBM’s complex brain microenvironment, such as low oxygen tension (e.g. 1% O2), vasculature-related stromal cells (e.g. human umbilical vein endothelial cells (HUVEC), human dermal fibroblasts (HDF) and growth factors (e.g. VEGF, bFGF), support the GBM angiogenesis.