In fact, when scrutinizing with SeqCode the ChIP-seq profiles of RING1B (a PRC1 subunit) for Ewing sarcoma (EWS)41, we confirmed (i) the good performance of the RING1B KD, and (ii) a striking decrease in the binding of the EWSR1-FLI1 fusion protein, which is responsible for the EWS disease, upon KD of RING1B (Fig. 7b). The gene discussed is EWSR1; the disease is Ewing sarcoma.