PI3K-Akt signaling, cAMP signaling, focal adhesion, calcium signaling, oxytocin signaling, apelin signaling, ECM-receptor interaction, and thyroid hormone signaling are those pathways which are commonly enriched for both the cases differential expression and mutation in HNSCC which gives higher significance to these pathways for the selected disease while there are specific pathways for DEGs and mutated genes lists which means there are pathways which may be altered only because of overexpression of the genes or higher mutations rate. This evidence concerns the gene AKT1 and head and neck squamous cell carcinoma.