Studies that evaluated previously accepted SNPs41–45 related to tendinopathies within a broader genomic database have been done for caspase 8 - rs1045485, a disintegrin and metalloproteinase with thrombospondin motifs 14 (ADAMTS14) - rs4747096, bone morphogenetic protein-4 (BMP4) - rs2761884, COL5A1 - rs1134170, rs12722, rs3196378, fibrillin-rs331079, and stromelysin-1 (MMP3) rs591058, rs679620. This evidence concerns the gene MMP3 and disease of the tendon.