While we did not observe significant alterations within immune populations from non-tumor-bearing mice (Supplementary Fig. 7a–f), Treg-specific Cd177-KO led to a significant decrease of TI Treg cells (Fig. 6a) and some other significant changes of various immune cells within various tissues of tumor-bearing mice (Supplementary Fig. 8a–e). This evidence concerns the gene CD177 and neoplasm.