Considering that MeCP2 is a multivalent protein and its broad binding to chromatin, further research is warranted to investigate whether MeCP2 recruits any other chromatin remodeling factors or post-transcriptional regulators via forming the higher-order assemblies on chromatin and whether these condensates mediate the molecular functions of MeCP2 underlying the pathogenesis of RTT. This evidence concerns the gene SET and Rett syndrome.