To investigate a potential LTF behavior of both TFs in NEPC, we performed SE analysis by H3K27ac profiling of ASCL1 and NEUROD1 NEPCs, and found that all models showed SE activation in common at a number of TFs (INSM1 and NFIB) regardless of the tumor subtype (Fig. 2e, Supplementary Table 3, and Supplementary Data 2). This evidence concerns the gene INSM1 and neoplasm.