Numerous studies have revealed that activation of NLRP3 inflammasome in macrophages cells can sniff cellular damage [49, 55] and modulates inflammatory responses in cognitive impairment [44, 56], ALI [42], cancer [50], renal disease [21, 22], liver disease [55], and diabetes mellitus [45, 46]. The gene discussed is NLRP3; the disease is acute respiratory distress syndrome.