PCSK1 and hepatocellular carcinoma: MiaPaCa-2 and HepG2 as tumor cells, derived from PDAC and HCC, respectively, were challenged with increasing concentrations of ZZW-115 in the presence or not of Fer-1 (1 μM), Z-VAD-FMK (20 μM), or Nec-1 (40 μM) at 24, 48, and 72 h.