Consistent with our findings, reduced TIMP3 levels were reported to be accompanied by accumulation of Beclin1 and LC3 and increased autophagosomes under induction by decorin, a prototypical small leucine-rich proteoglycan (SLRP) that acts as a soluble tumor repressor that counteracts tumorigenic and angiogenic growth [50]. Here, BECN1 is linked to neoplasm.