TLR3 and cancer: Additionally, both anthracycline and oxaliplatin can promote type I IFN production in malignant cells through the stimulation of endosomal TLR3, although the precise anthracycline-elicited ligand(s) that stimulate TLR3 remain to be verified, but it can be posited that this cascade of cancer promoting action is the result of a maladjusted structure of self RNA that is released from dying or stressed cancer cells.