Although both GHRHR and SV1 are present in prostatic (45), breast (46), gastric (27), ovarian (47), pancreatic (37), lung (48), esophageal (17), oral (38, 49), and skin cancers (50), SV1 possess stronger mitogenic activities (36, 39, 40). The gene discussed is GHRHR; the disease is skin neoplasm.