GHRHR and cancer: While alternative splicing of the C-X-C chemokine receptor 3 (CXCR3) was linked to β-arrestin recruitment (4), expression of GHRHR splice variants could be induced by hypoxic microenvironment in solid tumors, leading enhanced glycolysis (17), suggesting that cancer-associated GPCR isoforms are not only a consequence of cellular adaptation but also have an effect on malignancy.