In our two tumor models, C170 treatment suppressed tumor growth and induced memory and effector activity as evidenced by the functional tumor suppression on rechallenge and functional effector activity (CD25, IFNγ and GZMB (Granzyme B) Intracranial (IC) staining) in response to EphA2 peptide pulsing. The gene discussed is EPHA2; the disease is neoplasm.