After additionally adjusting obesity, smoking, and drinking, TC, TG, LDL-C, HDL-C, compared with those in the lowest quartile, individuals in the highest quartile of serum ALT levels had associated with hypertension in males and females, with an OR (95% CI) of 1.681 (1.028, 2.751), and 2.802 (1.102, 7.124), respectively. This evidence concerns the gene GPT and obesity due to melanocortin 4 receptor deficiency.