Gsap selectively increases amyloid‐beta production (He et al., 2010), a protein that is aggregated in AD and inositol polyphosphate‐5‐phosphatase D (Inpp5d) is suggested to contribute to AD in a non‐amyloid‐beta‐dependent fashion (Efthymiou & Goate, 2017). This evidence concerns the gene GSAP and Alzheimer disease.