CASS4 and Alzheimer disease: Among the most enriched genes in the RFPHigh samples (Table S1) were Cass4 and Apba2 (or Mint2), which are involved in amyloid synthesis and AD (Beck et al., 2014; Ho et al., 2008) and genes associated with macrophage activation, like Akr1b3, Angptl7, and Ticam2 (Qian et al., 2016; Ramana et al., 2006; Seya et al., 2005).