Overexpression of ABCB1 in Madin-Darby canine kidney cells resulted in increased GlcCer, LacCer, and Gb3 (45), and ovarian cancer cells that overexpress ABCB1 have increased GlcCer (no change in GCS expression) and lower levels of LacCer and gangliosides (99). This evidence concerns the gene ABCB1 and ovarian carcinoma.