Regulation of co-expression of lncRNA-Met and lncRNAs-Nox4 is a core mechanism in the hepatic fibrosis process, which can enhance signal factors such as glutathione S-transferase α 3 [36], transforming growth factor-β 1 (TGF—β 1) [5] and platelet-derived growth factor D [37], by activating target genes and decreasing NADPH oxidase 4 [38]. The gene discussed is PDGFD; the disease is Hepatic fibrosis.