In the ischemic penumbra of stroke models, Chemokine ligand 2 (CCL2) levels increase as early as 6 h of reperfusion with peak levels (Dimitrijevic et al. 2007; Guo et al. 2014) with induction of leukocyte recruitment and disruption of BBB integrity (Fang et al. 2018). This evidence concerns the gene CCL2 and Stroke.