NPC1 and nasopharyngeal carcinoma: Due to recent reports on the main role of HSP70 in the maturation of the NPC1 protein (Nakasone et al. 2014), as well as the positive effects of upregulation of heat shock proteins in vitro in NPC and other lysosomal diseases (Mu et al. 2008; Yang et al. 2014; Zampieri et al. 2012; Macías-Vidal et al. 2014), this therapy has become a promising research topic (Mengel et al. 2020) Kirkegaard et al. 2017 undertook in vitro testing of arimoclomol in primary fibroblasts from NPC patients and in vivo in the Npc1−/− mouse model.