The AT1-AAs can promote the expression of endothelin 1 and injure the arterial intima by binding to the AT1-R.9 Angiotensin II type 1 receptor agonistic autoantibodies can also promote the proliferation of vascular smooth muscle cells by activating the ERK1/2 pathway and inducing aortic wall stiffening.10 Angiotensin II also stimulates the production of matrix metalloproteinases (MMPs) through various pathways.11 Matrix metalloproteinases are deeply involved in the pathogenesis of aortic dissection. This evidence concerns the gene AGTR1 and Aortic dissection.