AGT and Aortic dissection: The AT1-AAs can promote the expression of endothelin 1 and injure the arterial intima by binding to the AT1-R.9 Angiotensin II type 1 receptor agonistic autoantibodies can also promote the proliferation of vascular smooth muscle cells by activating the ERK1/2 pathway and inducing aortic wall stiffening.10 Angiotensin II also stimulates the production of matrix metalloproteinases (MMPs) through various pathways.11 Matrix metalloproteinases are deeply involved in the pathogenesis of aortic dissection.