Yet to our knowledge, and following exploration of the TCGA PanCancer Atlas dataset available via cBioportal (Cerami et al., 2012; Gao et al., 2013), an altered expression of AKT1, CAV1, THBS1, or TIMP2 has not been previously associated with progression to aggressive prostate cancer. The gene discussed is TIMP2; the disease is Familial prostate cancer.