Yet to our knowledge, and following exploration of the TCGA PanCancer Atlas dataset available via cBioportal (Cerami et al., 2012; Gao et al., 2013), an altered expression of AKT1, CAV1, THBS1, or TIMP2 has not been previously associated with progression to aggressive prostate cancer. This evidence concerns the gene AKT1 and Familial prostate cancer.