The circRNA BCRC-3 inhibits bladder cancer proliferation via the miR-182-5p/p27 axis,[13] while circABCB10 acts as an oncogene in osteosarcoma by sponging miR-203, and facilitates nonsmall cell lung cancer cell progression and migration through the miR-1252/FOXR2 axis.[14,15] Li et al[16] recently reported that several circRNAs are aberrantly expressed in the early stage of bladder cancer, and are therefore promising biomarkers for early diagnosis. This evidence concerns the gene FOXR2 and urinary bladder carcinoma.