Dysregulated MAPK signaling pathway is associated with cancer-related functions like tumor cell proliferation, differentiation, migration, senescence, and apoptosis.[38] PRKCB, the parent gene of hsa_circ_0038645, regulates the MAPK signaling pathway by phosphorylating the RAS signaling pathway (Fig. 4). The gene discussed is PRKCB; the disease is neoplasm.