FOXR2 and urinary bladder cancer: The circRNA BCRC-3 inhibits bladder cancer proliferation via the miR-182-5p/p27 axis,[13] while circABCB10 acts as an oncogene in osteosarcoma by sponging miR-203, and facilitates nonsmall cell lung cancer cell progression and migration through the miR-1252/FOXR2 axis.[14,15] Li et al[16] recently reported that several circRNAs are aberrantly expressed in the early stage of bladder cancer, and are therefore promising biomarkers for early diagnosis.